Advances in Hypoxia-Inducible Factor 1-Alpha and Ischemic Heart Disease

Ischemic heart disease, resulting from ischemic and anoxic cardiomyocytes, can lead to the abnormal metabolic activity which is able result in some serious diseases including cardiac failure, thrombus other deadly disease it also bad factor health of human. Besides, oxidative stress one most factors this destroy healthy tissue, protein so on. Hypoxia, as a signal, launch hypoxia-inducible 1-alpha lives cytoplasm. It transfers cell nucleus achieve its aim, means going bind 1-beta first, then start downstream promoters facilitate several target genes such vascular endothelial growth factor, inducible nitric oxide synthase, necessary enzyme glycolysis erythropoietin. Reactive oxygen species has been proved that, second messenger. At moment, influential for through pathways increased angiogenesis, promoting decreased reactive species. In review, we discussed advances hypoxiainducible disease.